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EC number: 202-216-2
CAS number: 93-08-3
Table 3:Body weight, body weight
change and pre-terminal deaths
Group/Step and Dose (mg/kg
Body weight (g)
Day of Death(Time of
Preterminal deaths (%)
(day 8 –
F: Female NA: Not Applicable mg:
milligram kg: kilogram g: gram
Note: G1/Step 1 was not considered for
results and assessment of toxicity as the food was provided before dosing
The acute oral toxicity study was
conducted to assess the toxicological profile of the test item as per
OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure) in
The dose formulation was prepared by
using Milli-Q water and administered as a single oral gavage to
overnight fasted (16 to 18 hours) female rats at each step. There were
no clinical signs of toxicity and pre-terminal deaths.
The stopping criteria met as 3
consecutive animals survive at the upper bound. Hence, the further
dosing was stopped as per AOT 425 Stat program result (version: 1.0).
There were no clinical signs of toxicity and pre-terminal deaths.
The rats were observed for mortality
and clinical signs for 14 days post treatment. Body weights were
recorded prior to dosing on day 1 and on days 8 and 15. Necropsy was
performed for all the rats at termination. All survived rats gained
weight during experimental period. There were no gross pathological
changes at necropsy.
Based on the results of the present
study, the LD50 value of the given test chemical is >2000 mg/kg bw.
Thus, the test item is not classified for acute oral toxicity. CLP
criteria "Not Classified".
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