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EC number: 701-162-1
CAS number: -
Justification for the read-across approach using (Tetrapropenyl
succinimido)-caproic acid as supporting substance:
The registration substance (Pentapropenyl succinimido)-caproic acid and
proposed supporting substance (Tetrapropenyl succinimido)-caproic acid
are homolog series of (Polypropenyl succinimido)-caproic acid. The only
structural difference is that the alkyl moiety of the registratoin
substance is composed of five propylen unit, whereas that of the
supporting substance is composed of four propylen unit. The given
structural difference is not likely to be associated with significantly
deviating chemical reactivity, thus is not likely to be associated with
significantly deviating reactivity with genetic materials.
Evaluation of the genotoxicity of the registration substance
The read-across supporting substance is not mutagenic in Ames test, not
mutagenic in HPRT test. It is however clastogenic in in-vitro chromosome
aberration test and not clastogenic in in-vivo chromosome aberratoin
The assessment is based on the read-across approach. The overall
assessment on the read-across substance leads to the conclusion that the
registration substance is not likely to be genotoxic.
No classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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