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EC number: 701-162-1
CAS number: -
The acute toxicity of the registration substance is of no concern for oral or dermal routes.
The acute oral toxicity of the registration substance was investigated
according to the OECD Guideline 401. At dose of 2000 mg/kg bw no
significant effect was found.
The acute dermal toxicity of the registration substance was assessed
based on the read-across approach using
(Tetrapropylensuccinimido)-caproic acid as read-across supporting
The acute dermal toxicity of (Tetrapropylensuccinimido)-caproic acid was
investigated according to the OECD Guideline 402. At dose level of 2000
mg/kg bw no systemic effect was observed.
Acute oral toxicity
The acute oral toxicity of
the registration substance was investigated according to the OECD
Guideline 401. At dose of 2000 mg/kg bw no significant effect was found.
Acute dermal toxicity
The assessment was performed by
use of read-across approach
Justification for the read-across approach using
(Tetrapropylensuccinimido)-caproic acid as supporting substance:
registration substance (Pentapropylensuccinimido)-caproic acid and
proposed supporting substance (Tetrapropylensuccinimido)-caproic acid
are homologous series of (Polypropylensuccinimido)-caproic acid. The
only structural difference is that the alkyl moiety of the registratoin
substance is composed of five propylen unit, whereas that of the
supporting substance is composed of four propylen unit. The given
structural difference is not likely to be associated with significantly
deviating acute dermal toxicity, because neither the skin penetration
capacity nor the chemical reactivity is likely to be strongly influenced
by the given structural difference.
Evaluation of the acute dermal toxicity of the registration substance
read-across supporting substance did not induce any systemic effect in
the acute dermal toxicity study. Likewise no significant acute dermal
toxicity for the registration substance can be derived. Also the
observed low oral acute toxicity of the registration substance is
supporting the low acute dermal toxicity.
The acute toxicity of the registration substance is of no concern for
oral or dermal routes. No classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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