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EC number: 701-162-1
CAS number: -
Skin Reactions in the Pretest:
Necrosis was observed at 5% after 24 hours. Erythema and blanching was
observed at 1% after 24 hours. Erythema was observed at 0.2 %.
Epidermal Pretest: Erythema of score up to 2 was observed at 100%.
Erythema of score 1 and scaling was observed at 30 and 10 %. No effect
was found at 3%.
Skin Reactions in the Main Test:
The expected and commonly observed findings after FCA injection such as
erythema, oedema, necrotizing dermatitis, encrustation and exfoliation
of encrustation were noted.
No skin reaction were observed in the control group after treatment with
purified water. Discrete or patchy erythema was observed in 8 of 10 test
group animals 24 hours after treatment with 100% test item. Discrete or
patchy erythema was still observed in 2 test group animals 48 hours
after treatment with 100% test item.
No skin reations were observed in any of the control and test animals
after the challenge with the highest tested non-irritating concentration
of 10% test item in purified water.
Body Weights Development in the Main Test:
The body weight of the animals was within the range commonly recorded
for animals of this strain and age.
The skin sensitization potential of the registration substance is
assessed by read-across approach using
(Pentapropylensuccinimido)-hexanoate, sodium and triethanolamine salt as
read-across supporting substance.
The read across supporting substance was investigated for its skin
sensitization potential according to the OECD Guideline 406.
The registration substance is a non skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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