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EC number: 701-162-1
CAS number: -
Justification for not
performing the LLNA:
The registration substance as well
as the read-across supporting substances are surfactants.
The experimentally obtained values for the surface tensions are 37.2
mN/m (at 90% saturation concentration and 20°C) for the registration
substance and 31.6 mN/m (at 1g/l and 20°C) and 38.2 mN/m (at 90%
saturation concentration and 20°C) for the read-across supporting
Justification for read-across
using (Pentapropenyl succinimido)-hexanoate, sodium and triethanolamine
salt as supporting substance.
The registraton substance is a
weak acid and the read-across supporting substance is the corresponding
weak base. When dissolved in water the read-across supporting substance
will be converted to the registration substance.
for the read-across approach using (Tetrapropenyl succinimido)-caproic
acid as supporting substance:
registration substance and proposed supporting substance are homolog
series of (Polypropenyl succinimido)-caproic acid. The only structural
difference is that the alkyl moiety of the registratoin substance is
composed of five propylen unit, whereas that of the supporting substance
is composed of four propylen unit. The given structural difference is
not likely to be associated with significantly deviating dermal
bioavailability and chemical reactivity. Comparable skin sensitization
potentials are expected.
sensitization property of the registration substance
Two read-across supporting substances were investigated according to
OECD 406. No significant skin sensitization property was found for both
substances. Likewise no significant skin sensitization property can be
derived for the registration substance.
The skin sensitization potential of the registration substance is
assessed based on the data on the read-across supporting substances. In
two GPMTs (Guinea Pig Maximization Test), no skin sensitzation property
was found. No classification is warranted for the registration substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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