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EC number: 905-806-4
CAS number: -
No toxicity observed in a short-term study (OECD 202) with Daphnia magna
at loadings up to 1000 mg/L. In this study the test substance was
stirred in water in the usual way (1000 rpm) prior to exposure to the
Although 3 aquatic invertebrate studies are available, two of them are
considered unreliable. These unreliable tests (Rhone-Poulenc, 1977) were
done with 4,4'-MDI, as they mainly tested the hydrolysis product,
4,4'-MDA. In both studies acute toxicity values were found to be greater
than 500 mg/L for Daphnia magna and Limnea stagnalis,
The study of Caspers et al (1986) was performed with polymeric MDI and
contained two different experiments, following the OECD 202 protocol. In
one experiment, PMDI was dispersed into water by high speed shearing
(24,000 rpm) instead of the usual stirring (magnetic, 1000 rpm). This
gave a 24h-EC50 of 129.7 mg/L, which was almost certainly due to the
significantly increased production of 4,4'-methylenedianiline (MDA), a
substance which is known to be relatively toxic to daphnids. It may be
considered that the 24h-EC50 of 129.7 mg/L is irrelevant because the
dispersing method used in this one experiment does not reflect a
situation that might occur in the real environment. The second
experiment used the normal stirring (1000 rpm) and gave a 24h-EC50 >
1000 mg/L. The result of the short-term toxicity test (24h-EC50 >1000
mg/L) (Caspers et al., 1986) was corroborated with the long-term
mecocosm studies (Heimbach, 1993), where no effects were seen on
zooplankton at loadings up to 10,000 mg/L. Although only a 24h value for
aquatic invertebrates is available, this value is considered to be
conclusive enough for this endpoint. Due to the rapid reaction with
water (hydrolysis T1/2 = 20 days), any attempt to determine the aquatic
toxicity, will be influenced by the toxicity of the hydrolysis products.
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