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Physical & Chemical properties

Water solubility

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Description of key information

West et al. (2008) provide an estimated water solubility of 6.8 mg/L at 25°C.

Key value for chemical safety assessment

Water solubility:
6.8 mg/L
at the temperature of:
25 °C

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Any experimental estimation of water solubility for MDI is questionable and therefore QSAR may be considered. The West et al. (2008) study was an uptodate and valid QSAR method (WSKOWWIN (v1.41) which is part of the Estimation Program Interface (EPI) Suite, v3.20.) to provide a water solubility value of 6.8 mg/L for 4,4'-MDI, which may be used for the CSA, although it is only of theoretical value.