Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the document should be considered a draft

Due to the high reactivity of the substances of the MDI category with water, bioaccumulation tests can in principle not be performed with these substances. However, one bioaccumulation test (OECD 305E) with 4,4'-MDI and a mesocosm study with PMDI with an indication of bioaccumulation potential have been performed.

No data are available on terrestrial bioaccumulation on any of the MDIs of the category approach. The reactivity of MDI with water, the low measured BCF in fish and the evidence of the mesocosm study, suggest that MDI has a low potential to bioaccumulate in terrestrial food-chains.