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EC number: 905-806-4
CAS number: -
test substance is covered by the category approach of methylenediphenyl
diisocyanates (MDI). Hence, data of the category substances can be used
to cover this endpoint. The read-across category justification document
is attached in IUCLID section 13. It is important to note that the MDI
category approach for read-across of environmental and human hazards
between the MDI substances belonging to the MDI category is work in
progress under REACH. Therefore the document should be considered a draft
Due to the transient existence of MDI substances in the environment,
only estimated values for water solubility, octanol-water partition
coefficient (log Kow), soil adsorption coefficient (log Koc), and other
inter-media partitioning parameters can be determined; and these numbers
have little scientific value or relevance. This has been demonstrated by
West (2008) for Toluenediisocyanate (TDI), which is similar to the MDI
substances in structure and reactivity. A sensitivity analysis of the
Level III fugacity model outputs for TDI showed that wide variation in
model inputs such as water solubility and log Kow had negligible impact
on the predicted environmental distribution and inter-media transport of
such a reactive substance. This modeling analysis showed that,
regardless of whether TDI (or in this case, MDI substances) are emitted
directly to air, water, or soil, > 99.5% of the emission will remain and
be degraded within the compartment to which emissions were made. Hence,
the transport and distribution of the MDI substances are governed by
their reactivity in environmental media, and properties such as water
solubility, log Kow, and soil adsorption coefficient are of no real
value and cannot be determined properly. No accumulation or inter-media
exchange of the MDI substances is expected in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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