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EC number: 203-804-1
CAS number: 110-80-5
Maternal observations: In the rats exposed to 250 ppm 2 -ethoxyethanol
there were reductions in hemoglobin, hematocrit and mean cell volume in
the red blood cells, but there were no effects at either 50 or 10 ppm.
Litter data: There was a higher level of preimplantation loss in all
exposed groups compared with controls, although this was statistically
significant only in the 10 and 50 ppm groups. The mean number of live
fetuses was reduced in the exposed groups compared with the controls,
and this was statistically significant in the 10 and 50 ppm groups but
not at 250 ppm. Total litter weight was statistically significantly
reduced in the 10 and 250 ppm groups, the reduction being most marked at
Maternal observations: There were no effects due to compound on body
weight gain or food consumption and no clinical abnormalities which
could be attributed to exposure to 2 -ethoxyethanol.
Litter data: There was no evidence for any treatment-related effects on
the litter data. There were two major defects in the 175 ppm group: one
fetus had a cardiovascular defect (heart and aorta reduced in size and
the right subclavian artery was missing), and another fetus had a
ventral wall defect (umbilical hernia). The incidence of skeletal
defects was statistically significantly greater in the 175 ppm than in
the control group, largely as a result of retarded ossification of the
skeleton and an increased incidence of 27 presacral vertebrae. The
incidence of minor skeletal defects was also increased in the 10 ppm
group in comparison with the control group but is not considered to be
treatment-related, as it was not statistically significant and there was
only a very slight increase observed in the 50 ppm group. Taken overall,
the results of the two studies reported here for the effect of 2
-ethoxyethanol in rats and rabbits indicate that levels of 175 to 250
ppm may be around the threshold level for teratogenicity; 175 to 250 ppm
has been shown to be fetotoxic in both rats and rabbits, and 50 ppm is
mildly fetotoxic in rats, although there were no effects in rabbits.
These studies overall indicate a marginal fetotoxic effect level of 50
ppm and a clear no-effect level of 10 ppm in both species.
Remark of the author of this IUCLID dossier: According to the results in
rats the lowest administered dose (10 ppm) had effects on the litter
(higher level of preimplantation loss, reduction of mean number of live
fetuses, reduction of litter weight). Therefore this concentration is
considered to be the LOAEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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