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EC number: 203-804-1
CAS number: 110-80-5
Absorption and exposure concentration:
Under resting conditions, an average of 64% of inhaled 2 -ethoxyethanol
was retained. R(E) and Cl(atm) remained unchanged as exposure
concentration increased. The absorbed dose was apparently proportional to
the inhaled concentration and a linear relation between uptake rate and
exposure concentration was observed.
Absorption and physical exercise:
Cl(atm) and consequently rate of uptake increased when physical exercise
was performed during exposure. This was due not only to an increase in
the pulmonary ventilation rate but also to a slight increase in
retention. The increase of R(E), however, was not proportional to the
level of exercise since no difference was found between 30W and 60W.
Individual respiratory uptake of 2 -ethoxyethanol was governed mainly by
pulmonary ventilation, corrected for respiratory frequency, and the
concentration of the test substance in the air.
Respiratory elimination and exposure concentration:
The postexposure breath concentration of 2 -ethoxyethanol was measured
at regular times for four hours after the exposure period. Exhaled
concentrations declined quickly during the first minutes, since the
concentration after 7.5 minutes was only 1.5 + 0.6 % of the exhaled
concentration during exposure. Thereafter a much slower decrease was
observed to levels near the detection limit of the method. Postexposure
breath concentrations were higher as exposure concentration and consequently
Postexposure breath concentrations tended to be higher as the physical
workload increased but this tendency was not significant.
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