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EC number: 203-804-1
CAS number: 110-80-5
Subacute study results:
The most obvious effect was the marked reduction in survival of the high
dose groups (2000 mg/kg). Survival of the medium-dose group of male rats
(1000 mg/kg) was significantly reduced compared to the survival of the
control group. Survival of the low-dose group was not significantly
different to the control group.
Dose-related depressions in mean body weight were apparent in both male
and female rat studies. The mean body weights of the male and female
mouse groups treated with 2 -ethoxyethanol did not appear to differ
markedly from the control.
Testis of the high-dose male rats and mice were generally decreased in
size and testicular atrophy was seen. Additionally stomach ulcers were
observed in many of the high-dose male and female rats and the high-dose
Chronic study result:
Gross observations indicated that chronic treatment with 2
-ethoxyethanol at the medium und low dose levels caused an apparent
enlargement of the adrenal gland in male rats and interfered with the
development of spontaneous gross lesions of the spleen, pituitary, and
testis. In female rats the treatment caused a decrease in the incidences
of enlarged spleens and pituitaries and of subcutaneous masses in the
mammary gland region.
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