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EC number: 203-804-1
CAS number: 110-80-5
Results of dose-finding study:
No toxic signs were noted except ataxia on treatment days 9 and 10 in
the 2.0 mL/day group and on treatment day 10 in the 1.4 mL/day group.
Group mean body weights did not differ significantly from at any time,
and no dose-related changes were seen. Similarly, liver and kidney
weights were not altered by the 2 -ethoxyethanol treatments.
Results of teratology study:
No signs of maternal toxicity were noted except ataxia in the 0.5 mL
dose group in the last days of treatment. Mean maternal body weights of
the control and treated groups did not differ on days 1, 2, or 16, but
on day 21 each group differed significantly from the others. Significant
differences in maternal organ weights were seen only in the higher dose
group, in which maternal liver weights were reduced while kidney weights
were increased. There were no pregnant females with live fetuses in the
0.50 mL dose group, and only 11 of 21 pregnant females at the lower
dosage had live fetuses. In the 0.25 mL dose group, both the number of
live implants per litter and the mean body weight of fetuses were
significantly reduced. Only two externally visible malformations were
noted, both in fetuses from the 0.25 mL treatment group: one fetus had
an umbilical hernia, another had no tail. Visceral and skeletal
examiniations of live fetuses, revealed significantly increased
incidences of several defects in the 2 -ethoxyethanol- treated litters:
cardiovascular malformations and various types of deviations from normal
Remark of the author of this IUCLID dossier:
Since in the lowest dose group (1 mL per animal and day) malformations
in the offspring were observed, this value corresponds to the LOAEL.
With a density of 0.919 g/mL at 25 °C the daily applied amount was 919
mg/animal/day. With respect to the average body weight in that dose
group on day 21 of gestation (304 +/- 29 g) the applied concentration
was 3023 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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