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Key value for chemical safety assessment

Mode of Action Analysis / Human Relevance Framework

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According to Eastman Kodak (1992) repeated oral administration to rats causes necrosis of the liver, spleen, adrenal gland, and testis, as well as ulceration and perforation in the gastric area. Repeated inhalation exposure to the rat causes congestion of blood in the liver and lung, higher exposure rates causing blood congestion in the heart, kidney, and spleen, as well. Repeated spreading onto the skin causes inflammations in guinea pigs, and additionally causes necroses in rabbits.

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