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Workers - Hazard via dermal route

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Workers - Hazard for the eyes

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Source: Beratergremium für umweltrelevante Altstoffe (BUA) Vol:226 (2001) 71 p Abstract:

Toxicological Aspect. Data on the metabolism are missing. Investigations on rat hepatocytes have shown that monochloroacetone reacts directly with a biologically relevant macromolecule containing sulfhydryl groups and with glutathione. After splitting off the chloride ion, the compound may act as an alkylating agent. Monochloroacetone is a potent tear gas. In humans, monochloroacetone causes irritation of the eyes and upper respiratory tract. Skin contact causes painful blistering. In animal experiments, lung edema and hydrothorax were observed after inhalation exposure. Male rats are more sensitive to acute toxicity through inhalation than females. After oral and i.p. administration to the mouse and rat and dermal application to the rabbit, the compound shows comparable, very high acute toxicity. Repeated oral administration to rats causes necrosis of the liver, spleen, adrenal gland, and testis, as well as ulceration and perforation in the gastric area. Repeated inhalation exposure to the rat causes congestion of blood in the liver and lung, higher exposure rates causing blood congestion in the heart, kidney, and spleen, as well. Repeated spreading onto the skin causes inflammations in guinea pigs, and additionally causes necroses in rabbits. In an inadequately documented experiment in guinea pigs, no sensitizing effect was demonstrated. The available genotoxicity studies on bacteria, drosophila, and newts, none of which meets present methodical requirements, gave contradictory results and do not permit unequivocal conclusions. In the studies at hand, no tumor-initiating effect was shown. Carcinogenicity studies are not available.

General Population - Hazard via inhalation route

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General Population - Hazard via dermal route

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General Population - Hazard via oral route

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General Population - Hazard for the eyes

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