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EC number: 201-161-1
CAS number: 78-95-5
From the "BUA Stoffbericht"
Monochloroacetone is a potent tear gas. In humans, monochloroacetone
causes irritation of the eyes and upper respiratory tract. Skin contact
causes painful blistering. In animal experiments, lung edema and
hydrothorax were observed after inhalation exposure.
From HSDB database:
Chlroacetone gives off heavy vapors ... it causes much lacrimation
@ concn of 5 to 8 ppm in air, & @ higher concn causes clouding of cornea
which has not been described in detail. concn of 26 ppm in air is
intolerable for more than a min because of severe irritation of all
[grant, w.m. toxicology of the eye. 3rd ed., il: charles c. thomas
publisher, 1986., p. 207] **peer reviewed**
dermal application of chloracetone to stock mice in 183 days had
no tumorigenic effects, but 24 applications to albino mice, 0.2 ml, 0.3%
in acetone (promotion with croton oil, 0.2 ml, 0.3% in acetone, 20 wk),
in 365 days resulted in 44/19 papillomas, 10/20 papillomas in controls.
[searle, c. e. (ed.). chemical carcinogens. acs monograph 173.,
dc: american chemical society, 1976., p. 160] **peer reviewed**
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