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EC number: 201-161-1
CAS number: 78-95-5
Monochloroacetone has been examinded for mutagenic activity in several
different test systems. When E. coli were exposed to monochloroacetone,
it was found that the compound inhibited cell growth by 50%, but MCA did
not inhibit the cell division process.
(Loveless, J. Bacetiol. 1994). Monochloroacetone induced the frequency
of sex-linked lethals in Drosophila melanogaster. (Auerbach, Proc. R.
Soc. Edinburgh, 1947). Monochloroacetone produced increased mutations to
streptomycin nondependence in E. coli Sd-4 bacetria. The compound was
tested in the ames mutagenicity test using Salmonella typhimurium
strains TA 1535, TA 1537, Ta 98, TA 100 and hisG46 with and without a
liver microsomal metabolic activiation prepared from rats treated either
with Arochlor 1254 or phenobarbital. Monochloracetone was negative in
all strains tested at concentrations up to a 1 in 1500 dillution in the
standard plate incorporation assay. (Ames, Mutat. Research, 1975).
The available genotoxicity studies on bacteria, drosophila, and newts,
none of which meets present methodical requirements, gave contradictory
results and do not permit unequivocal conclusions. In the studies at
hand, no tumor-initiating effect was shown. Carcinogenicity studies are
not available. [cited from BuA Stoffbericht]
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