Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Monochloroacetone has been examinded for mutagenic activity in several different test systems. When E. coli were exposed to monochloroacetone, it was found that the compound inhibited cell growth by 50%, but MCA did not inhibit the cell division process.

(Loveless, J. Bacetiol. 1994). Monochloroacetone induced the frequency of sex-linked lethals in Drosophila melanogaster. (Auerbach, Proc. R. Soc. Edinburgh, 1947). Monochloroacetone produced increased mutations to streptomycin nondependence in E. coli Sd-4 bacetria. The compound was tested in the ames mutagenicity test using Salmonella typhimurium strains TA 1535, TA 1537, Ta 98, TA 100 and hisG46 with and without a liver microsomal metabolic activiation prepared from rats treated either with Arochlor 1254 or phenobarbital. Monochloracetone was negative in all strains tested at concentrations up to a 1 in 1500 dillution in the standard plate incorporation assay. (Ames, Mutat. Research, 1975).

The available genotoxicity studies on bacteria, drosophila, and newts, none of which meets present methodical requirements, gave contradictory results and do not permit unequivocal conclusions. In the studies at hand, no tumor-initiating effect was shown. Carcinogenicity studies are not available. [cited from BuA Stoffbericht]

Endpoint Conclusion:

Justification for classification or non-classification