Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1986
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: literature

Data source

Reference
Reference Type:
publication
Title:
Hazard evaluation of monochloroacetone
Author:
E.V. Sargent
Year:
1986
Bibliographic source:
Am. Ind. Hyg. Assoc. J 47(7); 375

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purtiy: approx. 93%

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified
Details on test animals and environmental conditions:
9 weeks old

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The test compound was held in contact with imperivious platic sheeting. Collars, desinged to prevent licking, were placed on the necks of the animals.
Duration of exposure:
24 hours
Doses:
50, 100, 200 and 400 mg/kg
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
141 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The dermal LD 50 was determined by Sargent et al to be 141 mg/kg.