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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system for solid test substance

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
BASF Test
This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C and 1025.2 hPa).
Several groups of 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, and the amount of air used during the exposure. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.
GLP compliance:
no
Test type:
other: Inhalation Hazard Test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Sodium acrylate
- Physical state: solid
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 135 g (mean)


ENVIRONMENTAL CONDITIONS
no details reported

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
approx. 0.025 mg/L
No. of animals per sex per dose:
6
Control animals:
no
Statistics:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: IHT
Effect level:
other: No dust formation was reported during generation of the test atmosphere. Due to the solid nature and low vapour pressure of the test substance, it can be expected that no test substance vapours were generated.
Exp. duration:
8 h
Remarks on result:
other: No mortalities after 8-h exposure to an atmosphere enriched with the test substance at 20°C.
Mortality:
No mortalities occurred.
Clinical signs:
The animals did not show any clinical signs of toxicity during or after exposure.
Body weight:
Body weights increased slightly within the 7-day study period up to a mean of 142 g.
Gross pathology:
At necropsy no abnormalities were observed.

Any other information on results incl. tables

No mortalities after 8-hour exposure to an atmosphere enriched with the test substance at 20°C. No dust formation was reported during generation of the test atmosphere. Due to the solid nature and low vapour pressure of the test substance, it can be expected that no test substance vapours were generated.

 

Applicant's summary and conclusion