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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
other: secondary source
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Evaluated as reliable for inclusion in review of data by BIBRA

Data source

Reference
Reference Type:
review article or handbook
Title:
Toxicology Profile Triethyl Citrate
Author:
BIBRA
Year:
1998
Bibliographic source:
BIBRA Toxicology Advice and Consulting, Citylink Centre, Railway approach, Wallington, Surrey, SM6 0DZ, UK.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: no information
Principles of method if other than guideline:
No information on method
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: aerosol
Details on inhalation exposure:
6 hours per day
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
62 days
Doses / concentrations
Remarks:
Doses / Concentrations:
296 ppm and higher
Basis:

No. of animals per sex per dose:
no data

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Effect level:
296 ppm
Based on:
test mat.
Basis for effect level:
other: Equivalent to 3344.86 mg/m3

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The repeated dose NOAEC for inhalation of triethyl citrate in rats is reported to be 296 ppm.