Registration Dossier
Registration Dossier
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EC number: 201-070-7 | CAS number: 77-93-0
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- other: secondary source
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Evaluated as reliable for inclusion in review of data by BIBRA
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicology Profile Triethyl Citrate
- Author:
- BIBRA
- Year:
- 1 998
- Bibliographic source:
- BIBRA Toxicology Advice and Consulting, Citylink Centre, Railway approach, Wallington, Surrey, SM6 0DZ, UK.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information
- Principles of method if other than guideline:
- No information on method
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triethyl citrate
- EC Number:
- 201-070-7
- EC Name:
- Triethyl citrate
- Cas Number:
- 77-93-0
- Molecular formula:
- C12H20O7
- IUPAC Name:
- triethyl citrate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Details on inhalation exposure:
- 6 hours per day
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 62 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
296 ppm and higher
Basis:
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 296 ppm
- Based on:
- test mat.
- Basis for effect level:
- other: Equivalent to 3344.86 mg/m3
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The repeated dose NOAEC for inhalation of triethyl citrate in rats is reported to be 296 ppm.
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