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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study not under GLP.

Data source

Reference
Reference Type:
publication
Title:
Toxicology of the Citric Acid Esters: Tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate
Author:
Finklestein M and Gold H
Year:
1959
Bibliographic source:
Toxicol. Applied Pharmacol. 1(3):283-292

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: No data
Principles of method if other than guideline:
Information on methods was not provided in this reliable textbook/review article. Practical handling experience has not resulted in the questioning of the accuracy of this data.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
No data

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
TEC was administered via oral gavage at 1 - 9.5ml/kg bw.
Doses:
1 - 9.5 ml/kg bw
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw
Based on:
test mat.
Mortality:
No data
Clinical signs:
Nausea, vomiting, ataxia, weakness, muscle twitching, tremors, reflex hypersensitivity, lowering of body temperature, gasping and shallow respiration, prostration, convulsions, respiratory failure and death.
Body weight:
No data
Gross pathology:
No gross abnormalities of the thoracic or abdominal organs that could be related to the toxic effects observed.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU