Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
The information does not come from a test report, and only minimum fields required can be filled in.

Data source

Reference
Reference Type:
other: database
Title:
Triethyl citrate, CAS# 77-93-0, RTECS# GE8050000
Author:
Canadian Centre for Occupational Health & Safety (CCOHS)
Year:
2010
Bibliographic source:
"Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63,p. 1892; cited in RTECS database (Registry of Toxic Effects of Chemical Substances, 2010)

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
peer-reviewed database
GLP compliance:
not specified
Remarks:
Peer-reviewed database, with no information on GLP status
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1 300 ppm
Based on:
not specified
Exp. duration:
6 h
Other findings:
Lungs, thorax or respiration:
- acute pulmonary oedema
- pleural effusion
- dyspnoea

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
LC50 (rat) = 1300 ppm/6h
Executive summary:

In the Registry of Toxic Effects of Chemical Substances (RTECS) database a LC50 (rat, inhalation) of 1300 ppm/6h is reported for triethyl citrate. No further details are available.