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EC number: 201-070-7
CAS number: 77-93-0
Table: Experimental results
Preparation hours post administra-tion
Number of cells scored
% aberrant cellsIncl. Gaps Excl. gaps
Mean mitotic index (%)
*** = p<0.0001
A chromosomal aberration study
according to OECD 475 was performed in rats in vivo after a single dose
of 2000 mg/kg bw O-Acetyltributyl citrate. Five animals per sex and
group, i.e. one vehicle control group, two test item groups and one
positive control group were employed for the study. The test item was
formulated in PEG 400. 24 and 48 h post-treatment, bone marrow cells
were collected and 100 well-spread metaphases/animal were scored for
chromosomal aberrations. Test item-treated animals showed reduction of
The mitotic index was slightly reduced
after 24 h, but the test substance did not induce chromosomal
aberrations at any time point investigated.
In contrast, the positive control
substance induced a highly significant effect documenting the
sensitivity of the test system. It
can be assumed that the same applies to triethyl citrate (CAS 77-93-0)
as it is a near analogue to the test substance acetyl tributyl citrate.
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