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EC number: 201-070-7
CAS number: 77-93-0
The affinity of triethyl-O-acetyl to the
enzyme is lower than that of triethyl citrate. The hydrolysis curve
shows an exponential course and the reaction rate is accelerated by the
extent that the acetyl group is cleaved.
The question which of the known esterases catalyses the enzymatic
hydrolysis of triethyl citrate and triethyl-O-acetyl is not easy to
answer. The liver esterase, which is also present in the blood serum,
seems not to be responsible for this. The pH optimum of the hydrolysis
is 9.0, a property that characterizes the pancreatic lipase. Also the
fact that chinine inhibits the hydrolysis of triethyl citrate at a
concentration of 1 *10E-3m to 15% and twice the concentration inhibits
to 30%, while atoxyl is without influence, speaks for the preference of
triethyl citrate and triethyl-O-acetyl to the lipase. A decision of this
question is possible only on the basis of studies on homogeneous enzyme
The substance of interest triethyl citrate
(TEC) and additionally triethyl-O-acetylcitrate (ATEC) were subject to
an investigation of their potential to hydrolyse in vitro (Bruns and
Werners, 1959). It was investigated, whether triethyl citrate and
triethyl-O-acetylcitrate are hydrolysed by a) liver homogenates and b)
blood serum. The esters triethyl citrate and triethyl-O-acetyl-citrate,
used as plasticizers, are hydrolysed by liver homogenate of human, rat
and mouse origin, and by blood serum to citric acid and ethanol or
acetic acid, citric acid and ethanol, respectively. Per mole of triethyl
citrate 1 mol if citric acid and 3 moles of ethanol are formed during
complete hydrolysis. In case of triethyl-O-acetylcitrate a further 1 mol
of acetic acid is build. These three metabolites are known to appear in
intermediary metabolism, where they are oxidized in well-defined paths
in the organism to CO2 and H20.
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