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EC number: 208-031-3 | CAS number: 506-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Eicosanoic acid was found to be non-genotoxic.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Multicase model A2H
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- bacteria, other: Salmonella sp.
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
- Metabolic activation system:
- no data
- Species / strain:
- bacteria, other: Salmonella sp.
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium sp. it was estimated that Eicosanoic acid does not exhibit positive gene mutation effect. - Executive summary:
Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium sp. it was estimated that Eicosanoic acid does not exhibit positive gene mutation effect.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Additional information from genetic toxicity in vitro:
Various studies were reviewed for genetic toxicity from reliable sources having Klimish rating 2 and 4 for the target and the read across substance for CAS: 506-30-9 considering the weight of evidence approach.
The summary of the results are presented below
Sr.No |
Endpoint |
Interpretation of Results |
Species/Strain |
Conclusion |
Sources |
1 |
In vitro Genetic toxicity |
Negative |
S. typhimurium Sp. |
Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium species it was estimated that Eicosanoic acid does not exhibit positive gene mutation effect. |
Predicted data for CAS : 506-30-9 |
2 |
Chromosome aberration |
Negative |
Chinese hamster Ovary (CHO) |
Based on the prediction for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO) it was estimated that Eicosanoic acid does not exhibit positive chromosomal effect. |
Predicted data for CAS : 506-30-9 |
3 |
Chromosome aberration |
Negative |
Chinese hamster Ovary (CHO K1) |
Based on the data for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO K1) cells it was found that Eicosanoic acid does not exhibit positive chromosomal and cytotoxic effect . |
Publication data for CAS : 506-30-9 |
4 |
In vitro Genetic toxicity |
Negative with and without metabolic activation |
Salmonella typhimurium strains TA100 , TA104 ,TA 1535, TA 97 and TA 98 |
In an Ames test , stearic acid, in dimethyl sulfoxide from doses 10 - 10000 µg/plate was not mutagenic in Salmonella typhimurium strains TA100 , TA104 , TA 1535, TA 97 and TA 98 with and without addition of S9 liver microsome fractions from Aroclor induced rats.The same has been obtained for hamsters as well. |
Publication data for RA CAS : 57-11-4 |
Based on the above results it can be concluded that substance CAS: 506-30-9 is expected to show the similar toxicological effect based on the effects observed on the other category members. Thus it is concluded that the substance is non-genotoxic. Thus Eicosanoic acid is considered to be non-mutagenic as the per the CLP regulation.
Justification for selection of genetic toxicity endpoint
Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium it was estimated that Eicosanoic acid does not exhibit positive gene mutation effect.Also the prediction for chromosomal abberation Based on in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO) was estimated that Eicosanoic acid does not exhibit positive chromosomal effect .
Justification for classification or non-classification
Eicosanoic acid is considered to be non-mutagenic as the per the CLP regulation.
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