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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil - docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid - in cultured Chinese hamster cells
Author:
Sasaki, Yu. F.; Sakaguchi, Masaayuki; Yamagishi, Tatsunori; Yamada, Hiroshi; Shirasu, Yasuhiko
Year:
1994
Bibliographic source:
Mutation Research; vol. 320; nb. 1/2; (1994); p. 9 - 22

Materials and methods

Principles of method if other than guideline:
Data is from Mutation Research
GLP compliance:
not specified
Type of assay:
in vitro mammalian chromosome aberration test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Eicosanoic acid
- Molecular formula: C20H40O2
- Molecular weight: 312.53
- Substance type:organic
- Physical state:solid

Method

Species / strain
Species / strain:
Chinese hamster Ovary (CHO)
Additional strain characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
no data
Test concentrations with justification for top dose:
5 - 20 mg/l

Results and discussion

Test results
Species / strain:
Chinese hamster Ovary (CHO)
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity:
no
Vehicle controls valid:
not specified
Negative controls valid:
not specified
Positive controls valid:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Based on the data for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO K1) cells it was found that Eicosanoic acid does not exhibit positive chromosomal and cytotoxic effect .
Executive summary:

Based on the data for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO K1) cells it was found that Eicosanoic acid does not exhibit positive chromosomal and cytotoxic effect .