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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
Year:
1987
Bibliographic source:
Journal of the American College of Toxicology.(Mary Ann Liebert,Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.Volume(issue)/page/year: 6(3),321,1987
Reference Type:
review article or handbook
Title:
RTECS NUMBER : WI2800000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);Journal of the American College of Toxicology.(Mary Ann Liebert,Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.Volume(issue)/page/year: 6(3),321,1987

Materials and methods

Principles of method if other than guideline:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Stearic acid to rat by the oral route.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):Stearic acid
- Molecular formula :C18H36O2
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
4 640 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Non toxic to rats.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Lowest published lethal dose (LDLo) of Stearic acid in rat was found to be 4640 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Stearic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of Stearic acid to rat by the oral route. The Lowest published lethal dose (LDLo) of Stearic acid in rat was found to be 4640 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Stearic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.