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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
Year:
1987
Bibliographic source:
Journal of the American College of Toxicology.(Mary Ann Liebert,Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.Volume(issue)/page/year: 6(3),321,1987
Reference Type:
review article or handbook
Title:
RTECS NUMBER : QH4375000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.Discontinued.Volume(issue)/page/year: 6(3),321,1987

Materials and methods

Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):Myristic acid
- Molecular formula :C14H28O2
- Substance type:Organic

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
100 mg

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: Mildly irritating to the eyes of rabbit.

Applicant's summary and conclusion

Interpretation of results:
other: mild irritant
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Eye irritation tests performed by the method of Standard Draize test,100 mg of Myristic acid applied to the eyes of rabbits,resulted in a mild irritation effect." The substance Myristic acid is thus considered "mildly irritating."
Executive summary:

Eye irritation tests performed by the method of Standard Draize test,100 mg of Myristic acid applied to the eyes of rabbits,resulted in a mild irritation effect." The substance Myristic acid is thus considered "mildly irritating."