Registration Dossier
Registration Dossier
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EC number: 208-031-3 | CAS number: 506-30-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In the absence of toxico-kinetic data for Eicosanoic acid, data from two read-across chemicals have been used.Docosanoic acid as well as Stearic acid have low dermal absorption; similar to Eicosanoic acid. Also the vapour pressure of all the 3 chemicals is low. Thus exposure via the dermal and inhalation route is unlikely. Given that long chain fatty acids are poorly absorbed, they shall be bio-accesible in the living system at low levels. The predicted bio-concentration values for the 3 chemical are also very low.
Considering all of the above, it has been assumed that the bio-accumulation potential of Eicosanoic acid shall be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Presented below is a summary of the property of the target chemical as well as the two read across chemicals; that belong to the same category of saturated fatty acids as the target chemical.
Property |
506-30-9 (Eicosanoic acid) |
112-85-6 (Docosanoic acid) |
57-11-4 (Read across – Stearic Acid) |
Physical state |
Solid |
Solid |
Solid |
Vapor Pressure (hPa at 25oC) |
0.00000004 |
0.00000065 |
0.000000963 |
Water Solubility (mg/L) |
44 (@33oC) |
0.016 |
0.597 |
Log Kow |
1.574 (@33oC) |
9.91 |
8.23 |
Rapid Biodegradation |
Yes |
Yes |
Yes |
Bio-concentration factor BCF |
3.2 |
3.2 |
10 |
Dermal absorption mg/cm2/event (Source: DEPA) |
0.00010 (Very low) |
0.00005 (Very low) |
0.00026 (Very low) |
From the above table, it is evident that Eicosanoic acid exhibits properties (that can influence bio-accumulation) similar to the two read across chemicals except water solubility that has an impact on Log Kow. Thus, it can be concluded that Eicosanoic acid shall have low bio-accumulation potential.
In the absence of toxico-kinetic data for Eicosanoic acid, data from two read-across chemicals have been used.Docosanoic acid as well as Stearic acid have low dermal absorption; similar to Eicosanoic acid. Also the vapour pressure of all the 3 chemicals is low. Thus exposure via the dermal and inhalation route is unlikely. Given that long chain fatty acids are poorly absorbed, they shall be bio-accesible in the living system at low levels. The predicted bio-concentration values for the 3 chemical are also very low.
Considering all of the above, it has been assumed that the bio-accumulation potential of Eicosanoic acid shall be low.
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