Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

In the absence of toxico-kinetic data for Eicosanoic acid, data from two read-across chemicals have been used.Docosanoic acid as well as Stearic acid have low dermal absorption; similar to  Eicosanoic acid. Also the vapour pressure of all the 3 chemicals is low. Thus exposure via the dermal and inhalation route is unlikely. Given that long chain fatty acids are poorly absorbed, they shall be bio-accesible in the living system at low levels. The predicted bio-concentration values for the 3 chemical are also very low.

Considering all of the above, it has been assumed that the bio-accumulation potential of Eicosanoic acid shall be low.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Presented below is a summary of the property of the target chemical as well as the two read across chemicals; that belong to the same category of saturated fatty acids as the target chemical.

Property

506-30-9

(Eicosanoic acid)

112-85-6

(Docosanoic acid)

57-11-4 (Read across – Stearic Acid)

Physical state

Solid

Solid

Solid

Vapor Pressure (hPa at 25oC)

0.00000004

0.00000065

0.000000963

Water Solubility (mg/L)

44 (@33oC)

0.016

0.597

Log Kow

1.574 (@33oC)

9.91

8.23

Rapid Biodegradation

Yes

Yes

Yes

Bio-concentration factor BCF

3.2

3.2

10

Dermal absorption mg/cm2/event (Source: DEPA)

0.00010 (Very low)

0.00005 (Very low)

0.00026 (Very low)

 

From the above table, it is evident that Eicosanoic acid exhibits properties (that can influence bio-accumulation) similar to the two read across chemicals except water solubility that has an impact on Log Kow. Thus, it can be concluded that Eicosanoic acid shall have low bio-accumulation potential.

In the absence of toxico-kinetic data for Eicosanoic acid, data from two read-across chemicals have been used.Docosanoic acid as well as Stearic acid have low dermal absorption; similar to  Eicosanoic acid. Also the vapour pressure of all the 3 chemicals is low. Thus exposure via the dermal and inhalation route is unlikely. Given that long chain fatty acids are poorly absorbed, they shall be bio-accesible in the living system at low levels. The predicted bio-concentration values for the 3 chemical are also very low.

Considering all of the above, it has been assumed that the bio-accumulation potential of Eicosanoic acid shall be low.