Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The lethal concentration (LC50) value of Eicosanoic acid in aquatic invertebrate [Daphnia magna] in a 48 hr study on the basis of mortality effect was estimated to be 5.7 mg/L. Based on this LC50 value,the substance may qualify for the aquatic classification.But after compairing with other CLP criteria for BCF and biodegradation it is concluded that Eicosanoic acid does not exhibit toxicity to aquatic invertebrate (Daphnia magna) i.e. it is non hazardous to the aquatic environment.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
5.7 mg/L

Additional information

Based on weight of evidence approach the no.of studies were reviewed for short-term toxicity to aquatic invertebrates from reliable sources having Klimish rating 2 and 4.

The summary of the results are presented below

Sr. No

Endpoint

Value

Duration

Basis of effect

Species

Sources

1.

LC50

5.7 mg/L

 48 hr.

Mortality

Daphnia magna

Predicted data from QSAR for CAS : 506-30-9

2.

EC50

1.22 mg/L

48 hr.

Immobilization

Daphnia magna

Predicted data from QSAR for CAS : 506-30-9

3.

EC50

>5 mg/L

48 hr.

Immobilization

Daphnia magna

Experimental data from study report for RA CAS : 112-85-6

4.

LC50

40 mg/L

3 hr

Mortality

Daphnia pulex

Experimental data for RA CAS : 8002-13-9

 

Based on the studies summarized in the above table for the target substance Eicosanoic acid and the read across substance,the endpoint value was found to vary between lethal concentration (LC50) = 5.7 mg/L to 40 mg/L and effective concentration (EC50) = 1.22 mg/L to >5 mg/L in a 3 hrs. to 48 hrs.study on the basis of mortality and immobilization effect. Based on the LC50 and EC50 values, ,the substance may qualify for the aquatic classification.But after compairing with other CLP criteria for BCF and biodegradation it is concluded that Eicosanoic acid does not exhibit toxicity to aquatic invertebrate (Daphnia magna and Daphnia pulex ) i.e. it is non hazardous to the aquatic environment.