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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
[R]: 3.58E3 mg/kg; Estimation for LD50 for CAS 506-30-9
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR Toolbox version 3.1

Materials and methods

Principles of method if other than guideline:
The prediction is done using QSAR toolbox version 3.1
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Eicosanoic acid
- Molecular formula: C20H40O2
- Molecular weight: 312.53
- Substance type:organic
- Physical state:solid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hours
No. of animals per sex per dose:
5 males and females
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 575.76 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Effects not observed.

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

(("a" and "b" )  and ("c" and "d" )  )

Domain logical expression index: "a"

Similarity boundary:Target: C(=O)(O)CCCCCCCCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (original)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 7

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 10.1

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lethal dose (LD50) of Eicosanoic acid in New Zealand White rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to New Zealand White rabbit by the dermal route. The lethal dose (LD50) of Eicosanoic acid in rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.