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EC number: 905-898-6
CAS number: -
Diethanolamine (DEA) which is present at levels up to a maximum of 25% in the multiconstituent substance is a skin and a severe eye irritant in rabbits.
A patch test with two
rabbits comparing the irritation potential of pure and technical DEA
dermally applied for 1, 5, 15 min or 20 h under occlusive conditions is
available. Both compounds led to slight skin irritation after 1 - 15
min, while distinct irritation was noted after 20 h (BASF AG, 1968). The
mean erythema and edema scores for 24, 48 and 72 hours in case of 20 h
exposure were 2 and 1.33, respectively (note that erythema was present
at 72 hours, while edema was absent at 72 hours). At 72 hours, in one
red-yellowish necrosis was observed, while the other one showed a
spotted appearance. At day 8, in both animals strong desquamation was
Triethanolamine was found not irritating to rabbit skin.
A study on pure and
technical DEA is available for assessment. A volume of 0.1 ml was
instilled in the rabbit’s eyes and the animals were observed for 8 days.
Observations at 24, 48 and 72 h revealed severe signs of irritation
consisting of superficial corrosion, distinct corneal opacity,
conjunctival bleeding, distinct conjunctival redding, distinct oedema
and conjunctival scale with no reliable difference between the pure and
the technical product indicating a severe damage to ocular tissue (BASF
was found not irritating to rabbit eye.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Based on the data
available and the harmonised classification for diethanolamine, which is
present at levels up to 25 % in the substance, the substance is
classified as Xi; R38 (irritating to skin) and R41 (risk of serious
damage to eyes).
According to EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008, the classification is H315, Cat. 2 and
H318, Cat. 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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