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EC number: 905-898-6
CAS number: -
The acute oral toxicty for the substance was > 2000 mg/kg bw. Acute toxicity data indicate low toxicity for triethanolamine, the major constituent: in rats the oral LD50 was 6400 mg/kg bw; in rabbits the dermal LD50 was > 2000 mg/kg bw. Inhalation exposure for 8 hours to vapour saturated with TEA failed to cause any deaths in rats (LC50 was not determined).
In an acute oral toxicity study in the rat according to the acute toxic
class method, six Sprague-Dawley rats were dosed with 2000 mg/kg bw via
gavage. There were no mortalities and no clinical signs of toxicity.
Body weight gain was as expected and no abnormalities were noted on
necropsy (Safepharm, 2000)
In an acute oral toxicity study (BASF AG, 1966), 5 Sprague-Dawley
rats/sex/dose were exposed to 200 - 6400 mg/kg bw TEA by gavage and
observed for 7 days. The LD50 was determined to be 6400 mg/kg bw for
males and females. No deaths occurred at doses of 5000 mg/kg bw or
below. At 200 mg/kg bw, slight agitation was observed up to 4 hours
after exposure; at higher doses unsteady, elevated respiration, anancasm
to chew, apathy, and reduced grooming was noticed. Two days after
exposure, no clinical signs were observed. Gross pathology did not
reveal any abnormalities.
In a dermal limit test, rabbits were treated with 2000 mg/kg bw TEA on
the intact or abraded skin and subsequently observed for a 14 -day
period (EPA, 1989a). The test substance was either derived from NH3 (92%
TEA) or DEA (88% TEA), both containing approximately 6.5% DEA. Mild
erythema was observed following exposure to TEA derived from NH3 on the
intact or abraded skin, returning to normal on day 6. Moderate erythema
was observed following exposure to TEA derived from DEA on the intact or
abraded skin, returning to normal on day 10. No mortality was observed,
hence the LD50 was > 2000 mg/kg bw.
Due to its extremely low volatility, there is
a lack of data documenting the acute inhalation toxicity. As
good quality data for the oral and dermal route are available, in
accordance with column 2 of REACH Annex VIII, a study regarding the
inhalation route is not required. One
limited report stated that whole-body exposure of rats to a saturated
TEA atmosphere (approximately 1.8 mg/m3) at 20°C for 8 hours failed to
cause any deaths. Therefore no LC50 value has been determined for this
compound (BASF AG, 1966).
Based on the acute oral toxicity data for the substance, and for
the acute toxicity data of the major constituent TEA, and the minor
constituent DEA, no classification for acute toxicity is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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