Reaction mass of 2,2',2''-nitrilotriethanol and 2,2'-[[2-[(2-hydroxyethyl)amino]ethyl]imino]bisethanol and 2,2'-iminodiethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Due to the low vapour pressure, the technically highest attainable concentration is approximately 1.8 mg/m3 (0.29 ppm) when the test substance is evaporated at 20°C (concentration not determined), which is below any limit concentration.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Inhalation risk test

GLP compliance:

no

Test type:

other: Inhalation risk test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2',2''-nitrilotriethanol

EC Number:

203-049-8

EC Name:

2,2',2''-nitrilotriethanol

Cas Number:

102-71-6

Molecular formula:

C6H15NO3

IUPAC Name:

2,2',2''-nitrilotriethanol

Details on test material:

- Name of test material (as cited in study report): Triethanolamine

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Saturated TEA atmosphere (concentration not given).

No. of animals per sex per dose:

6 males, 6 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: saturated TEA atmosphere (approximately 1.8 mg/m3)

Exp. duration:

8 h

Mortality:

0/12

Clinical signs:

other: no clinical signs reported

Body weight:

mean body weight gain: 17.25 g

Gross pathology:

1 chronic bronchitis, all other animals without findings