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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
The study was published in 1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1958

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The material was tested on normal rabbit eyes as a 20% suspension in propylene glycol. Observations were made 1, 24 and 48 h after application and any injury scored according to the method of Draize (1955)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Remarks:
Albino
Details on test animals or tissues and environmental conditions:
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Body weights were 2.0 - 3.2 kg
- Housing: Not reported
- Diet: Not reported
- Water: Not reported
- Acclimation period: Not reported

ENVIRONMENTAL CONDITIONS: Not reported

Test system

Vehicle:
other: Propylene glycol
Controls:
not specified
Amount / concentration applied:
Amount applied: 0.1 mL of a 20% suspension in propylene glycol
Duration of treatment / exposure:
Single instillation on Day 1
Observation period (in vivo):
48 h
Number of animals or in vitro replicates:
not specified
Details on study design:
STUDY DESIGN
The test material was applied as a 20% suspension in propylene glycol on the center of the cornea

REMOVAL OF TEST SUBSTANCE
-Washing: No

OBSERVATIONS
- Irritation: Readings were made at 1, 24 and 48 hours, with the corneas unstained and then stained with a 2% solution of fluorescein sodium. Injury was scored according to the method of Draize (1955)

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks:
according to the method of Draize (1955)
Basis:
mean
Time point:
24/48 h
Score:
45
Max. score:
120
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Remarks:
Severely irritating

Applicant's summary and conclusion

Interpretation of results:
other: Eye irritation scores ahoed Diglycidyl resorcinol to be severely irritating
Conclusions:
In an eye irritation study with rabbits, the eye irritation scores showed Diglycidyl resorcinol to be severely irritating
Executive summary:

The substance was tested in an eye irritation test in rabbits. The results showed that the substance is a severe ocular irritant.