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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
This study was submitted for publication in 1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins

Data source

Reference
Reference Type:
publication
Title:
The Toxicology of Epoxy Resins
Author:
Hine CH, Kodama JK, Anderson HH, Simonson DW, Wellington JS.
Year:
1958
Bibliographic source:
AMA Archives of Industrial Health

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Diglycidyl resorcinol was tested for effect on the skin of rabbits. Albino rabbits were clipped over the back and flank and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilised an multiple rabbit holder (Lang, 1944), and patches of gauze secured over the areas with adhesive taps. The compounds were introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resins removed, and a first reading made. After 72 hours a second reading was made. Any irritation was scored according to the method of Draize (1955) - the maximum possible score was 8.
GLP compliance:
no
Remarks:
pre-GLP study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Specific details on test material used for the study:
Diglycidyl resorcinol; no other details reported.

Test animals

Species:
rabbit
Strain:
not specified
Remarks:
Albino
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.0 - 3.2 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported
Duration of treatment / exposure:
24 hours
Observation period:
72 Hours
Number of animals:
Males; number not specified
Details on study design:
Diglycidyl resorcinol was tested for effect on the skin of rabbits. Albino rabbits were clipped over the back and flank and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilised an multiple rabbit holder (Lang, 1944), and patches of gauze secured over the areas with adhesive taps. The compounds were introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resins removed, and a first reading made. After 72 hours a second reading was made. Any irritation was scored according to the method of Draize (1955) - the maximum possible score was 8.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Remarks:
reading after 24 and 72 hours
Time point:
72 h
Score:
5
Max. score:
8
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Remarks:
Moderately irritating

Applicant's summary and conclusion

Interpretation of results:
other: Moderately irritating with a score of 5
Remarks:
According to Draize, compounds producing combined averages (primary irritation indices) above 6 are considered severe irritants
Conclusions:
In a skin irritation study with rabbits, diglycidyl resorcinol was applied to the back and flanks of albino rabbits. Based on the results of this study, the substance is considered to be irritating to skin
Executive summary:

The substance was tested in a skin irritation test in rabbits. Exposure to the test item was 24 hours. The mean irritation score of 24 and 72 hours was 5 (maximal score 8). The substance is considered to be moderately irritating to skin. This result is used as weight of evidence with other studies to justify the irritating property of diglycidyl resorcinol to skin.