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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The Toxicology of Epoxy Resins
Author:
Hine CH, Kodama JK, Anderson HH, Simonson DW, Wellington JS.
Year:
1958
Bibliographic source:
AMA Archives of Industrial Health
Reference Type:
publication
Title:
The Toxicology of Glycidol and Some Glycidyl Ethers
Author:
Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH
Year:
1956
Bibliographic source:
AMA Arch Indust Health 14:250-264
Reference Type:
publication
Title:
Toxicology and safe handling of CBP-55 (Technical 1-chloro-3-romopropene-1)
Author:
Hine CH, Anderson HH, Moon HD, Kodama JK, Morse M, Jacobsen NW
Year:
1953
Bibliographic source:
AMA Arch Indust Hyg, 7: 118-136

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of six rats were exposed to saturated vapors of diclycidyl resorcinol at 30±1 °C within 8 hours, by passage through the liquids in two fritted glass bubblers connected in series in a glass chamber of 19.5 L capacity. The motor-driven syringe assembly delivered measured amounts of the test compound from a 10 mL. Luer-Lok syringe into an evaporator through which metered air moved at a uniform rate. The air flow was set at approximately 3 to 11 L per minute, depending on the concentration desired. Nominal concentrations were calculated by the standard gas-concentration formula of Jacobs and were checked by determining the total quantity of material vaporized.
GLP compliance:
no
Remarks:
pre-GLP
Test type:
other: 8-hour exposure to saturated vapors (the maximum attainable concentration)
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: commercial laboratory in Gilroy, California
- Weight at study initiation: 110-150 g
- Housing: six to a cage
- Diet: standard laboratory pellets
- Water: tap water
- Acclimation period: for about two weeks

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 14 and 18

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Motor-driven syringe assembly: Luer-Lok syringe into an evaporator through which metered air moved at a uniform rate
- Exposure chamber volume: 19.5 L
- Method of holding animals in test chamber: 6 animals/chamber
- Method of conditioning air: high concentration was obtained by bubling air through a fritted glass disc immersed in the compound, which was held in a glass container
- Source and rate of air: air flow was set at 3 to 11 L/min, depending on the concentration desired
- Temperature, humidity, pressure in air chamber: 30±1 °C
Analytical verification of test atmosphere concentrations:
no
Remarks:
the concentration was too low to permit accuracy of determination
Duration of exposure:
8 h
Concentrations:
saturated vapour of diglycidyl resorcinol
No. of animals per sex per dose:
6 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing: noted weighing changes
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Statistics:
one level tested

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
other:
Remarks:
the maximum attainable concentration
Effect level:
other: the maximum attainable concentration
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
Not reported
Clinical signs:
other: Not reported
Body weight:
Not reported
Gross pathology:
Not reported
Other findings:
No systemic toxicity has resulted from inhalation of the saturated vapours

Applicant's summary and conclusion

Interpretation of results:
other: no toxicity hazard could be associated at the maximum attainable concentration
Conclusions:
The test item diglycidyl resorcinol does not need to be classified as no toxicity hazard could be associated at the maximum attainable concentration.
Executive summary:

The six rat males of the Long-Evans strain (bw 110 -150 g) were exposed with the saturated vapor of diglycidyl resorcinol for eight hours.

The authors concluded that no practical toxicity hazard could be associated.