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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 January 2018 - 24 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
not specified
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Source and lot/batch No.of test material: 53715080
- Storage condition of test material: Room temperature in the dark
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
ca. 28.7
Temp.:
30 °C
pH:
ca. 5.7
Details on results:
The result from the preliminary estimate indicated that the HPLC method was suitable for determination of the partition coefficient. As the test item does not contain any modes of dissociation, testing was performed at approximately neutral pH with the test item in a non-ionized form. The main component in the chromatography was determined to be approximately 88% by area percentage normalization This is consistent with the test item being a mono-constituent and as such, the partition coefficient of the main peak has been reported.
Conclusions:
The partition coefficient of the test item has been determined to be 28.7, log10 Pow 1.46.

Description of key information

The partition coefficient of the test item has been determined to be 28.7, log10 Pow 1.46.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.46
at the temperature of:
20 °C

Additional information