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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
The data for this study was accepted for publication on 01 July 1957
Reliability:
other: The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose:
other: Publication

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1958

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single administration was given to male rats of the Long-Evans strain. The animals were observed for the following 10 days, and those that died were subjected to necropsy. At the end of the observation period, the survivors were killed for necropsy, and sections of their tissues were preserved in 10% formalin for histologic examination. LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952). The test item diluted with propylene glycol was given intragastrically to rats.
GLP compliance:
no
Test type:
other: SIngle intragastric adminstration
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Specific details on test material used for the study:
No data

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals and environmental conditions:
Male rats (110-150 g), Long-Evans strain

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Details on oral exposure:
The test material was given to male rats (110-150 g) as a single Intragastric administration by means of a ball-point needle and syringe - dose level not reported

VEHICLE
- Concentration in vehicle: 10%
- Amount of vehicle (if gavage): not available
- Justification for choice of vehicle: not available
Doses:
No dose level reported
No. of animals per sex per dose:
five or six males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed and sections of their tissues were preserved in 10% formalin for histologic examination.
- LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948)
- Other examinations performed: clinical signs
Statistics:
LD50 values with their confidence limits were calculated according to the method of Litchfield and Wilcoxon (1948)

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
2 570 mg/kg bw
Based on:
test mat.
95% CL:
2 200 - 3 000
Mortality:
not reported
Clinical signs:
Moderate depression, slight dyspnea. In surviving animals loss of weight and diarrhoea. Animals that died within 48 hours had a blood-tinged nasal discharge.
Body weight:
not reported
Gross pathology:
nonspecific, chief effect of local irritation
Other findings:
none

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral toxicity test showed an LD50 of 2570 mg/kg
Executive summary:

Acute oral toxicity: In this study, male rats were administered the resorcinol diglycidyl ether. No administered dose, no number of animals, no mortality or body weight details are reported. The acute oral LD50 for the substance in male rats was determined to be 2570 mg/kg