Registration Dossier
Registration Dossier
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EC number: 202-987-5 | CAS number: 101-90-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- This study was accepted for publication on 01 July 1957
- Reliability:
- other: The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 958
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- m-bis(2,3-epoxypropoxy)benzene
- EC Number:
- 202-987-5
- EC Name:
- m-bis(2,3-epoxypropoxy)benzene
- Cas Number:
- 101-90-6
- Molecular formula:
- C12H14O4
- IUPAC Name:
- 2-({3-[(oxiran-2-yl)methoxy]phenoxy}methyl)oxirane
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- Diglycidyl resorcinol; no details reported
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male rats (110-150 g), Long-Evans strain
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- propylene glycol
- Details on exposure:
- Single I.P. injection
- Doses:
- Not reported
- No. of animals per sex per dose:
- not reported
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed and sections of their tissues were preserved in 10% formalin for histologic examination.
- LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952)
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 132 - < 241 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none reported
- Clinical signs:
- none reported
- Body weight:
- not reported
- Gross pathology:
- not reported
- Other findings:
- none reported
Applicant's summary and conclusion
- Conclusions:
- The acute intraperitoneal LD50 for the substance in male rats was determined to be 178 mg/kg
- Executive summary:
Acute intraperitoneal toxicity: In this study, male rats were administered the resorcinol diglycidyl ether. The no mortality, clinical signs, body weight or necropsy details are reported.The acute intraperitoneal LD50 for the substance in male rats was determined to be 178 mg/kg
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