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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
This study was accepted for publication on 01 July 1957
Reliability:
other: The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1958

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Specific details on test material used for the study:
Diglycidyl resorcinol; no details reported

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals and environmental conditions:
Male rats (110-150 g), Long-Evans strain

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
propylene glycol
Details on exposure:
Single I.P. injection
Doses:
Not reported
No. of animals per sex per dose:
not reported
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed and sections of their tissues were preserved in 10% formalin for histologic examination.
- LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952)

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 132 - < 241 mg/kg bw
Based on:
test mat.
Mortality:
none reported
Clinical signs:
none reported
Body weight:
not reported
Gross pathology:
not reported
Other findings:
none reported

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal LD50 for the substance in male rats was determined to be 178 mg/kg
Executive summary:

Acute intraperitoneal toxicity: In this study, male rats were administered the resorcinol diglycidyl ether. The no mortality, clinical signs, body weight or necropsy details are reported.The acute intraperitoneal LD50 for the substance in male rats was determined to be 178 mg/kg