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EC number: 451-620-7
CAS number: 352230-22-9
28-day LC50 value
of 813 mg/kg dry weight and a 28 day IC50 value
of 767 mg/kg dry weight have been determined for the effects of D5 on
mortality and reproduction of Folsomia candida. A
NOEC of 377 mg/kg dry weight has been determined by the reviewer on the
basis of a visual examination of the data for both mortality and
There are no data describing the long-term toxicity of the registered
substance to terrestrial arthropods. However, an OECD TG 222 earthworm
reproduction study is being conducted with the registered substance. The
earthworm is the standard organism for soil macroorganisms and there is
no indication that arthropods would be any more susceptible.
In the interim period, before the data with the registration substance
become available, data are read across from the siloxane
decamethylcyclopentasiloxane (D5, CAS: 541-02-6) with terrestrial
A 28-day LC50 value of 813 mg/kg dry weight and a 28-day IC50
value of 767 mg/kg dry weight have been determined for the effects of
the test substance on mortality and reproduction of Folsomia candida
(Velicogna et al., 2011). A NOEC of 377 mg/kg dry weight has been
determined by the reviewer on the basis of a visual examination of the
data for both mortality and reproduction.
This data will be considered in the derivation of the PNECsoil of the
Read-across of the terrestrial toxicity data for D5 to Reaction Mass of
3,3,5,5-tetraphenylhexamethyltetrasiloxane (CAS 352230-22-9) is
considered to be suitable to derive an interim hazard and risk
assessment under REACH until the studies with the registration substance
Refer to IUCLID Sections 6.0 and 6.3 (CSR Sections 7.0 and 7.2) for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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