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EC number: 451-620-7
CAS number: 352230-22-9
>4074 mg/kg dry weight and 56-day NOEC ≥4074 mg/kg dry weight, for the
effects of D5 on mortality and reproduction and growth, respectively, of Eisenia
>41 mg/kg dry weight and 56-day NOEC ≥41 mg/kg dry weight (measured
concentrations), for the effects of D5 on survival and reproduction,
respectively, of Eisenia fetida.
There are currently no
reliable data describing the long-term toxicity of the registered
substance to soil macroorganisms.
An OECD TG 222 earthworm
reproduction test is being conducted with the registered substance
according to ECHA final decision TPE-D-2114497761-36-01/F. The substance
dataset and risk assessment will be updated once results of the study
are available and the study is finalised.
A preliminary OECD TG 222 limit test has been
conducted with the registered substance at a concentration of 1000 mg/kg
dry weight. Effects were observed at the limit concentration. A full
dose response test is therefore being carried out. which began on 26th
May 2021. Days 28 and 56 will be the 23rd of June and the 21st of July,
respectively. The final study report is expected to be available in
October 2021, based on the schedule provided by the test laboratory. As
soon as the final report is available the PNECs and chemical safety
assessment will be updated. It is anticipated that the revised dossier
will be completed by the end of December 2021.
In the interim period,
before the data with the registered substance become available, data are
read across from the siloxane decamethylcyclopentasiloxane (D5, CAS
541-02-6; EC No. 208-764-9).
A 28-day LC50 value
of >4074 mg/kg dry weight and a 56-day NOEC of ≥4074 mg/kg dry weight
(measured initial concentration) have been determined for the effects of
the test substance on mortality and reproduction and growth respectively
of Eisenia andrei (Velicogna et al., 2011).
No effects at the highest
concentration tested were also determined in a second test with D5: 28-d
F0 LC50 values of >76 mg/kg nominal concentration, >41 mg/kg
mean measured concentration, and NOECs of 76 mg/kg nominal
concentration, and 41 mg/kg mean measured concentration, have been
determined for effects of D5 on survival and weight change of adult
56-day F1 LC50
values of >76 mg/kg nominal concentration, >41 mg/kg mean measured
concentration, and NOECs of 76 mg/kg nominal concentration, and 41 mg/kg
mean measured concentration, have been determined for effects of D5 on
reproduction of the earthworm Eisenia fetida (Smithers Viscient,
Read-across of the
terrestrial toxicity data for D5 to Reaction Mass of
3,3,5,5-tetraphenylhexamethyltetrasiloxane (CAS 352230-22-9; EC No.
451-620-7) is considered to be suitable to derive an interim hazard and
risk assessment under REACH until the studies with the registered
substance are available.
Refer to IUCLID Sections 6.0
and 6.3 (CSR Sections 7.0 and 7.2) for further discussion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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