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EC number: 451-620-7
CAS number: 352230-22-9
Terrestrial testing is not an
Annex VIII requirement for Reaction Mass of
3,3,5,5-tetraphenylhexamethyltetrasiloxane (CAS 352230-22-9; EC No.
451-620-7). However, the low water solubility, high log Kow and
high log Koc of the substance indicate that it will adsorb to
organic matter and partition to sludges in a wastewater treatment plant.
No effects were observed in the short-term aquatic toxicity tests. As
the substance is poorly water soluble and the aquatic data available are
based on WAFs, it is more appropriate to use terrestrial data to assess
the potential toxicity of the substance in the environment.
OECD TG 222 earthworm
reproduction, OECD TG 208 seedling emergence and growth and OECD TG 216
soil microorganism tests have been conducted with the registered
substance in accordance with ECHA final decision
A 28-day NOEC of ≥1000 mg/kg
dry weight has been determined for the effects of the test substance on
mortality of Eisenia fetida; a 28-day NOEC of 125 mg/kg dry
weight has been determined for the effects of the test substance on body
weight of Eisenia fetida; 56-day NOEC and EC10
values of 62.5 mg/kg dry weight and 62.62 mg/kg dry weight,
respectively, have been determined for the effects of the test substance
on reproduction of Eisenia fetida (Smithers ERS Ltd., 2021).
Effect concentrations are
based on nominal concentrations because measured concentrations remained
within 20% of nominal for the duration of the test.
values for mortality, body weight and reproduction are equivalent to
≥3030, 379 and 190 mg/kg dry weight, respectively, when normalised to 2%
14-day NOEC values of ≥1000
mg/kg dry weight were determined for the effects of the test substance
on the survival, emergence and dry shoot weight of six plant species,
based on nominal concentrations (Smithers, 2020). The species tested
were cabbage (Brassica oleracea), corn (Zea mays),
cucumber (Cucumis sativus), onion (Allium cepa), soybean (Glycine
max) and tomato (Lycopersicon esculentum). No effects were
observed. The test was conducted in accordance with OECD TG 208 and in
compliance with GLP. The NOEC values are equivalent to ≥1176 mg/kg dry
weight when normalised to 2% organic carbon content.
28-day EC50, EC10
and NOEC values of >100, >100 and ≥100 mg/kg dry weight have been
determined for the effects of the test substance on the nitrogen
formation rate of soil microorganisms, based on nominal concentrations.
These values are equivalent to >357, >357 and ≥357 mg/kg dry weight when
normalised to 2% organic carbon content.
The studies are all
considered to be reliable and the test organisms will have been exposed
to the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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