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EC number: 200-820-0
CAS number: 74-89-5
Mitchell et al., Methylamine in human urine, Clinica Chimica Acta 312 (2001) 107–114
Mitchell et al. investigated in 2001
the excretion of MMA after ingestion of different dietary
sources. Methylamine is the simplest aliphatic amine found
in human urine. The average daily output of methylamine was 11.00 ±8.17
mg (12.73 ±9.35 male; 9.27 ± 6.35 female) with a range of values
spreading from 1.68 to 62.30 mg. Dietary studies suggested that certain
fish and seafoods (clam, crab, haddock, halibut, octopus, tuna) and
fruit and vegetables (pear, peas, tomato) may add to this urinary
output. Ingestion of creatinine also increased urinary methylamine
levels.Chemical and dietary precursor studies indicated that there was
no major exogenous source of this amine and suggested that the origin of
the majority of human urinary methylamine is endogenous with only subtle
contributions from the diet. Additionally pretreatment with neomycin
sulfate showed that endogenous bacterial metabolism does not contribute
to a significant production and urinary excretion of methylamine.
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