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EC number: 200-820-0
CAS number: 74-89-5
The biodegradability of methylamine
hydrochloride was investigated according to MITI-I (OECD 301C) and
published by the Official Bulletin of Economy, Trade and Industry
(1988). 30 mg/L activated sludge and 100 mg/L of the test substance were
used in this test. The time duration was 2 weeks, whereby the indirect
analysis showed a result of 84 % degradation, based on BOD (NH3). Direct
analysis results are given as 96 %, based on TOC and 100 %, based on
The target substance methylamine and
the source substance methylammonium chloride used in this study belong
to the group of primary aliphatic amines. The solvation of both,
methylamine and methylammonium chloride in water results in solutions of
the methylammonium cation (common "breakdown product"). Both respective
counterions are naturally and ubiquitous occurring ions and are also to
a certain extent required for the maintenance of various body functions.
Besides the influence on the pH value of an aqueous solution (OH-), they
do not bear a relevant intrinsic property, allowing one in general to
focus on the methylammonium cation. The methylammonium cation is
believed to act and to be metabolised by the same mechanisms by
microorganisms and by other classes of living organisms.
Therefore both substances are expected
to follow the same toxicokinetic pattern.
OECD 301C: The substance Monomethylammonium chloride is readily biodegradable.
biodegradability of monomethylamine has been investigated within
different experimental settings.
In the key
study (Official Bulletin of Economy, Trade and Industry, 1988), the
biodegradability of monomethylamine was determined according to MITI-I
(OECD 301C). This experiment was conducted with the almost identical
substance methylamine hydrochloride. 30 mg/L activated sludge and 100
mg/L of the test substance were used in this test. The time duration was
2 weeks, whereby the indirect analysis showed a result of 84 %
degradation, based on BOD (NH3). Direct analysis results are given as 96
%, based on TOC and 100 %, based on HPLC, respectively. The substance
was, thus, considered as readily biodegradable.
supporting study (Chudoba et al., 1969), the oxygen consumption of
activated sludge exposed to methylamine was studied using respirometers
(aerobic conditions). The oxygen consumption by endogenous respiration
was recorded whereby two different sets of tests were set up
(non-adapted sludge; adapted sludge). The exposure period in both sets
was 13 days. The test substance concentration amounts to 66.7 mg/L. The
removal of methylamine from the test samples by biodegradation was also
determined by studying the chemical oxygen demand. Within 13 days the
following results are reported for methylamine: BOD/ThOD = 67.8 %
(non-adapted sludge); BOD/COD = 93.5 % (adapted sludge).
supporting study (BASF AG, 1990), monomethylamine was investigated in a
study similar to OECD 301F. The exposure duration was 28 days and the
test substance concentration was 400 mg/L, based on test material.
Degradation of 55 % occurred within 28 days under aerobic conditions.
The authors report that ammonia or ammonium release may lead to an
impaired degradation due to a shift in pH. If this shift in pH does not
occur, biological degradation is possible. As inoculum domestic,
activated sludge (without adaption) was used. According to this test,
the substance is not readily biodegradable. However, due to high
substance concentration (400 mg/L), it is assumed that the pH of the
test solutions has been influenced leading to a decreased degradation
rate as mentioned by the authors. pH values are only reported for the
end of the test. Neither additional pH values for other points in time
nor information about pH adjustments are available.
supporting study (Chemservice S.A., 2010), the biodegradability of the
substance monomethylamine was calculated based on QSAR methods by using
EPIWIN (BIOWIN v4.10). Seven different models are used by this tool to
predict an overall result if the substance is readily biodegradable or
not. As newest model, Biowin 7 predicts additionally the biodegradation
ability under anaerobic conditions. According to the Linear and also
Non-linear Model monomethylamine is biodegrading fast. The Ultimate
Biodegradation Timeframe is given in weeks, whereas the Primary
Biodegradation Timeframe shows days. Both MITI Models predict that the
substance is readily biodegradable, which is also the overall conclusion
of the calculation. Under anaerobic conditions monomethylamine is
suspected to be biodegraded fast as well.
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