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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental results of test chemicals
Justification for type of information:
Data for the target chemical is summarized based on the test chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as- 2. and 3.
GLP compliance:
not specified
Transformation products:
not specified
pH:
7
Temp.:
20 °C
DT50:
135 yr
Type:
not specified
Remarks on result:
other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
pH:
8
Temp.:
20 °C
DT50:
14.6 yr
Type:
not specified
Remarks on result:
other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
pH:
9
Temp.:
20 °C
DT50:
1.5 yr
Type:
not specified
Remarks on result:
other: Acid and based catalyzed hydrolysis rate constant is 12600 & 0.0015 L/mol-sec, respectively.
pH:
7
Type:
not specified
Remarks on result:
other: test chemical is not hydrolysable
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Executive summary:

Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

The first study was reviewed from authoritative database (HSDB) in this study the half-life and acid & base catalyzed hydrolysis rate constant of the test chemical was determined at a temperature of 20°C. The acid and based catalyzed hydrolysis rate constant of test chemical was determined to be 12600 & 0.0015 L/mol-sec, respectively with a corresponding half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively.

In another study the Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes and No neutral hydrolysis is evident.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.

Key value for chemical safety assessment

Additional information

Various studies have been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

The first study was reviewed from authoritative database (HSDB) in this study the half-life and acid & base catalyzed hydrolysis rate constant of the test chemical was determined at a temperature of 20°C. The acid and based catalyzed hydrolysis rate constant of test chemical was determined to be 12600 & 0.0015 L/mol-sec, respectively with a corresponding half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively.

In another study the Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes and No neutral hydrolysis is evident.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively at 20 deg C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.