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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Long term toxicity of test chemical were determine on the freshwater aquatic invertebrate daphnia magna.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
- Water flea
Test type:
flow-through
Water media type:
not specified
Total exposure duration:
21 d
Reference substance (positive control):
no
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
31.138 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: Neutral Organic SAR
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of no effects observed in a freshwater system, the NOEC value for the substance is estimated to be 31.138 mg/l for aquatic invertebrate for 21 days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of no effects observed in a freshwater system, the NOEC value for the substance is estimated to be 31.138 mg/l for aquatic invertebrate for 21 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Description of key information

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of no effects observed in a freshwater system, the NOEC value for the substance is estimated to be 31.138 mg/l for aquatic invertebrate for 21 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
31.138 mg/L

Additional information

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of no effects observed in a freshwater system, the NOEC value for the substance is estimated to be 31.138 mg/l for aquatic invertebrate for 21 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.