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Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27.09.2012-16.10.2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Experimental test result
Justification for type of information:
Data is from experimental study report
Qualifier:
according to
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Specific details on test material used for the study:
- Name of test material: N-tert-Butylacrylamide
- Molecular formula: C7-H13-N-O
- Molecular weight: 127.1857g/mol
- Smiles notation: CC(C)(C)NC(=O)C=C
- InChl: 1S/C7H13NO/c1-5-6(9)8-7(2,3)4/h5H,1H2,2-4H3,(H,8,9)
- Substance type: organic
- Physical state: solid
Key result
Medium:
methanol
Solubility:
3 800 mg/L
Temp.:
28 °C
Remarks on result:
other: soluble
Conclusions:
The experimental value of solubility of N-tert-butylacrylamide in methanol at 28°C was determine to be 3800 mg/L indicating that this substance is soluble in methanol.
Executive summary:

The experimental value of solubility of N-tert-butylacrylamide in methanol at 28°C was determine to be 3800 mg/L indicating that this substance is soluble in methanol.

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27.09.2012-16.10.2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Experimental test result
Justification for type of information:
Data is from experimental study report
Qualifier:
according to
Guideline:
other: Soxhlet/Solvent extraction method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Specific details on test material used for the study:
- Name of test material: N-tert-Butylacrylamide
- Molecular formula: C7-H13-N-O
- Molecular weight: 127.1857g/mol
- Smiles notation: CC(C)(C)NC(=O)C=C
- InChl: 1S/C7H13NO/c1-5-6(9)8-7(2,3)4/h5H,1H2,2-4H3,(H,8,9)
- Substance type: organic
- Physical state: solid
Key result
Medium:
other: Petroleum ether
Solubility:
3 200 mg/L
Temp.:
28 °C
Remarks on result:
other: soluble
Conclusions:
The experimental value of solubility of N-tert-butylacrylamide in Petroleum ether at 28°C was determine to be 3200 mg/L indicating that this substance is soluble in Petroleum ether.
Executive summary:

The experimental value of solubility of N-tert-butylacrylamide in Petroleum ether at 28°C was determine to be 3200 mg/L indicating that this substance is soluble in Petroleum ether.

Description of key information

The experimental value of solubility of N-tert-butylacrylamide in methanol at 28°C was determine to be 3800 mg/L indicating that this substance is soluble in methanol.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
3 800 mg/L

Additional information

Gravimetric method was used to determine the solubility of the substance in organic solvent. The experimental value of solubility of N-tert-butylacrylamide in methanol at 28°C was determine to be 3800 mg/L indicating that the substance is soluble in methanol. Using the Soxhlet/Solvent extraction method the solubility of the substance in Petroleum ether is observed to be 3200 mg/L at 28°C, indicating that the substance is soluble in petroleum ether.