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EC number: 214-244-2
CAS number: 1117-31-3
Based on read-across from Ethylene diacetate (CAS 111-55-7) and Propane-1,2-diyl diacetate (CAS 623-84-7):
Oral: LD50 = 6860 mg/kg bw
Inhalation: LC0 = 0.845 mg/L
Dermal: LD50 > 2000 mg/kg bw
Justification for grouping of substances and read-across
There are no data available on the acute toxicity of
1,3-Butylene diacetate (CAS 1117-31-3). In order to fulfil the
standard information requirements set out in Annex VIII, 8.5, in
accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006,
read-across from structurally related substances is conducted.
In accordance with Article 13 (1) of Regulation (EC) No
1907/2006, "information on intrinsic properties of substances may be
generated by means other than tests, provided that the conditions set
out in Annex XI are met.” In particular for human toxicity,
information shall be generated whenever possible by means other than
vertebrate animal tests, which includes the use of information from
structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances
and read-across approach laid down in Annex XI, Item 1.5, of
Regulation (EC) No 1907/2006, whereby physicochemical, toxicological
and ecotoxicological properties may be predicted from data for
reference substance(s) by interpolation to other substances on the
basis of structural similarity, Ethylene diacetate (CAS 111-55-7) and
Propane-1,2-diyl diacetate (CAS 623-84-7) are selected as reference
substances for assessment of acute toxicity.
The read-across is based on the structural similarity between
the source and target substances which are all esters of similar
di-functional alcohols with the carboxylic acid acetic acid. A
detailed analogue approach justification is provided in the technical
dossier (see IUCLID Section 13).
Overview of Acute toxicity
Molecular weight (g/mol)
Acute toxicity, oral
RA CAS 111-55-7
Experimental result: LD50 = 6860 mg/kg bw
Acute toxicity, inhalation
RA CAS 623-84-7
LC0 = 0.845 mg/L
Acute toxicity, dermal
Experimental result: LD50 > 2000 mg/kg bw
(a) The substance subject to the REACh
Phase-in registration deadline of 31 May 2013 is indicated in bold
font. Only for this substance a full set of experimental results
and/or read-across is given.
(b) Reference (read-across) substances are
indicated in normal font. Lack of data for a given endpoint is
indicated by “--“.
Acute oral toxicity
One acute oral toxicity study with Ethylene diacetate in rats is
available (Smyth, 1941). Ethylene diacetate as 50% dispersion in water
was administered to 10 male animals as single oral dose by stomach tube.
The observation period following administration was 14 days. The data
were calculated by the method of probits. The precision is indicated by
the range of 95% probability.
The resulting LD 50 value of the study in male rats was evaluated to be
6860 mg/kg bw.
Acute inhalation toxicity
The acute inhalation toxicity of Propane-1,2-diyl diacetate was
evaluated in a study equivalent to OECD guideline 403 (Dow, 1986). A
group of 6 male Fischer 344 rats were exposed whole body to the highest
attainable concentration of 129 ppm for 6 h. The animals were observed
for a period of 14 days following administration. No mortality occurred
and no clinical signs of toxicity were apparent and necropsy revealed no
Therefore, the LC0 for male rats was the highest attainable vapour
concentration of 129 ppm, corresponding to 0.845 mg/L.
Acute dermal toxicity
The acute dermal toxicity of Propane-1,2-diyl diacetate was
evaluated in a study according to OECD guideline 402 under GLP
conditions (Dow, 1986). A group of 10 New Zealand White rabbits (5 males
and 5 females) were treated with the undiluted test substance at the
limit dose of 2000 mg/kg bw under semiocclusive conditions for 24 h.
The animals were observed for a period of 14 days following
administration. During the study period, no mortality and no clinical
signs of toxicity occurred in any animal. Furthermore, no effects on
body weight and no substance-related findings during necropsy were
observed. Therefore, the LD50 value for males and females was greater
than 2000 mg/kg bw.
Conclusion for acute toxicity
In summary, an acute oral toxicity study with the structurally
related substance Ethylene diacetate (CAS 111-55-7) resulted in an oral
LD50 value of 6860 mg/kg bw.
For acute inhalation toxicity, a study with Propane-1,2-diyl
diacetate (CAS 623-84-7) is available. From the study, a LC0 value of
129 ppm (0.845 mg/L), the highest attainable vapour concentration, was
An acute dermal toxicity study conducted with Propane-1,2-diyl
diacetate (CAS 623-84-7) resulted in a dermal LD50 value > 2000 mg/kg bw.
Thus, the available data indicate a very low level of acute
toxicity for the target and source substances and thus no hazard for
acute oral, inhalative and dermal toxicity was identified.
Justification for selection of acute toxicity – oral endpoint
Hazard assessment is conducted by means of read-across from a structural analogue. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall quality assessment (refer to the endpoint discussion for further details).
Justification for selection of acute toxicity – inhalation endpoint
Justification for selection of acute toxicity – dermal endpoint
Based on read-across from analogue substances following an
analogue approach, the available data on acute, dermal and inhalation
toxicity of 1,3-Butylene diacetate (CAS 1117-31-3) do not meet the
criteria for classification according to Regulation (EC) 1272/2008 or
Directive 67/548/EEC, and the data are therefore conclusive but not
sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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