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EC number: 214-244-2
CAS number: 1117-31-3
ErC50 (72 h): > 100 mg/L (nominal) and > 60 mg/L (geometric mean) for Pseudokirchneriella subcapitata (OECD 201)
NOEC (72 h): ≥ 100 mg/L (nominal) and ≥ 60 mg/L (geometric mean) for Pseudokirchneriella subcapitata (OECD 201)
One GLP Guideline study is available investigating the effects of
1,3-butylene diacetate (CAS 1117-31-3) to aquatic algae (Vryenhoef,
2012). The study was performed according to OECD 201 with the freshwater
algae Pseudokirchneriella subcapitata. A range-finding test was
performed in order to define the exposure concentrations for the
definitive test. Concentrations of 0.1, 1.0, 10 and 100 mg/L did not
result in any effects on growth rate after 72 h. Thus, a limit test with
100 mg/L was performed. No effects on the growth rate were observed in
the definitive test as well. Thus, the ErC50 (72 h) was determined to be
> 100 mg/L (nominal). Chemical analysis of the test substance
concentration showed that the concentration of test substance dropped
from 107% of nominal at 0 h to 33% of nominal after 72 h. Therefore, the
concentrations were related to the geometric mean measured
concentrations to derive the EC50 value. In this case, the ErC50 (72 h)
was determined to be > 60 mg/L (geometric mean) based on the growth
inhibition. The decline of test concentrations was probably related to
instability of test substance.
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